1q: antitubercular drug contraindicated in pregnancy ?
a. streptomycin
b. rifampicin
c. INH
d. ethambutol
e. pyrazinamide
answer: a . streptomycin . there is no evidence that pyrazinamide is safe in pregnancy , so it should be avoided unless and until it is absolutely necessary .
2q: antimalarial drug to be avoided in pregnancy ?
a. chloroquine
b. quinine
c. primaquine
d. anti-folates
e.tetracyclines
answer: c and e . primaquine and tetracyclines . primaquine is known to cause hemolysis if the baby is G6PD deficient and tetracyclines cause dental damage .
3q: antiepileptic which is not associated with congenital malformation when used in pregnant women ?
a.phenytoin
b. phenobarbitone
c. carbamazepine
d. valproate
answer: b . phenobarbitone . carbamazepine is also relatively safe in pregnancy .
4q: which of the following antiepileptic is least likely to cause malformation in fetus during pregnancy ?
a. phenytoin
b. carbamazepine
c. sodium valproate
d. phenobarbitone
answer: d . phenobarbitone .
5q: consequence of maternal use of cocaine is ?
a. hydrops
b. sacral agenesis
c. cerebral infarction
d. hypertrichosis
answer: c . cerebral infarction .
6q: a pregnant mother is treated with oral anticoagulant . the likely congenital malformation that may result in the fetus is ?
a. long bones limb defect
b. cranial malformation
c. cardiovascular malformation
d. chondrodysplasia punctata
answer: d . chondrodysplasia punctata .
7q: which does not cross placenta ?
a. heparin
b. morphine
c. naloxone
d. warfarin
answer: a . heparin .
8q: a child born with multiple congenital defects including cleft palate , neural tube defect , ASD and microcephaly , which of the following drug was probably used by the mother ?
a. erythromycin
b. isotretinoin
c. ibuprofen
d. metronidazole
answer: b . isotretinoin
