*Mifepristone is a recently developed oral antiprogesterone agent.
*It also has antiandrogenic and antiglucocorticoid activity.
*It is used in the following conditions :
- Termination of pregnancy (MTP) - An abortificient.
~Termination is effective upto 9 weeks (63 days).
~Complete abortion occurs in 85% of cases with a single dose upto 6-7 weeks.
~A single oral dose of 600 mg is used.
- Post coital contraception :
~Mifepristone 600 mg given orally within 72 hours of intercourse.
~Interferes with implantation and is highly effective.
- Once a month contraception:
~Single 200 mg dose given 2 days after mid cycle each month prevents conception.
- Cervical ripening
- Induction of labour
- Cushing's syndrome : Mifepristone has glucocorticoid receptor blocking action. It is used for palliation in Cushing's syndrome with inoperable cases.
- Fibroids : Shrinking of uterine fibroids has been observed following mifepristone therapy.
- Ectopic pregnancy : Injection of mifepristone into the ectopic pregnancy (unruptured sac) causes its resolution.
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